Medical Books and Lectures notes - Free downloads

. By Vinay Kumar, MBBS, MD, FRCPath, Professor and Chairman, Department of Pathology, University of Chicago, Pritzker School of Medicine, Chicago, IL; Abul K. Abbas, MD, MBBS, Professor and Chair, Department of Pathology, University of California San Francisco School of Medicine, San Francisco, CA; and Nelson Fausto, MD, Chairman, Department of Pathology University School of Medicine, Seattle, WA First Prize (Basic and Clinical Sciences), 2005 BMA Awards " Continues the tradition of excellence that has characterized this textbook since its first edition...No serious student of disease, whether beginning, mature, or advanced, should be without this book ."-JAMA Robbins Pathological Basis of Disease is one of the best-selling medical textbooks of all time. Through 6 editions, it has become the one text that nearly all medical students purchase, and is widely used by practicing pathologists and physicians worldwide. The New Edition of this venerable textbo...

Definition of Neoplasia Neoplasia is new, uncontrolled growth of cells that is not under physiologic control. A "tumor" or "mass lesion" is simply a "growth" or "enlargement" which may not be neoplastic (such as a granuloma). The term "cancer" implies malignancy, but neoplasms can be subclassified as either benign or malignant. There is no single mechanism by which a neoplasm arises. Many different mechanisms give rise to neoplasms, and that is what makes diagnosis and treatment so challenging. Nomenclature of Neoplasia Based upon origin: Malignant neoplasms arising from tissue embryologically derived from ectoderm or endoderm are usually carcinomas. Examples include: Squamous cell carcinoma of cervix Adenocarcinoma of stomach Hepatocellular carcinoma Renal cell carcinoma Malignancies arising from mesoderm (connective tissues) are usually sarcomas. Examples include: Leiomyosarcoma Chondrosarcoma Osteosarcoma Liposarcoma N...

INTRODUCTION AND OBJECTIVES: In this unit, we explore basic ideas about what "diseases" are, how they are produced, and how they are recognized. Details and further explanations are available in Chapter I of Robbins. Chapter I deals with cellular injury and cellular reactions to injury. "Injury" refers to the various agents and modalities that act on cells (such as, chemicals, toxins, organisms, intracellular accumulations, temperature changes, radiation, etc.). Cells can react by modifying themselves slightly and thus adapt to the injury (such as hypertrophy, hyperplasia, atrophy, and metaplasia, hydropic swelling, and fatty change). Such adaptations may be reversible. Cells can also react by becoming permanently altered and then living a new "lifestyle" (such as radiation changes in cells). They may also react to injury by being overwhelmed, and unable to continue life, and so they die. When cells die, they can do so in a pre- and proscribed...